Tyr-51 is the proton donor-acceptor for NAD(H)-dependent interconversion of xylose and xylitol byCandida tenuisxylose reductase (AKR2B5)
Author:
Publisher
Wiley
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.febslet.2008.11.003/fullpdf
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4. Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme;Bohren;Biochemistry,1994
5. Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110;Tarle;J. Biol. Chem.,1993
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