Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5′-triphosphate metabolite levels-Reference-Cited by-同舟云学术

Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5′-triphosphate metabolite levels

Published:2004-07-28 Issue:1-3 Volume:573 Page:38-44
ISSN:0014-5793
Container-title:FEBS Letters
language:en
Short-container-title:

Author:

Balzarini Jan,Aquaro Stefano,Hassan-Abdallah Alshaimaa,Daluge Susan M.,Perno Carlo-Federico,McGuigan Chris

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference29 articles.

1. 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

2. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

3. Unique purine crossover activation pathway for the potent anti-HIV agent 1592U89

4. Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity.

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