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Selective Kinase Inhibition by Exploiting Differential Pathway Sensitivity

  • Published:2006-04 Issue:4 Volume:13 Page:399-407
  • ISSN:1074-5521
  • Container-title:Chemistry & Biology
  • language:en
  • Short-container-title:Chemistry & Biology

Author:

Kung Charles,Kenski Denise M.,Krukenberg Kristin,Madhani Hiten D.,Shokat Kevan M.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference31 articles.

1. Exploring biology with small organic molecules;Stockwell;Nature,2004

2. Protein kinases—the major drug targets of the twenty-first century?;Cohen;Nat. Rev. Drug Discov.,2002

3. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors;Chang;Chem. Biol.,1999

4. Features of selective kinase inhibitors;Knight;Chem. Biol.,2005

5. “Spare” alpha 1-adrenergic receptors and the potency of agonists in rat vas deferens;Minneman;Mol. Pharmacol.,1984

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