Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

Author:

Larkin Paul B.,Sathyasaikumar Korrapati V.,Notarangelo Francesca M.,Funakoshi Hiroshi,Nakamura Toshikazu,Schwarcz Robert,Muchowski Paul J.

Funder

NIH

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference91 articles.

1. Kynurenines in the mammalian brain: when physiology meets pathology;Schwarcz;Nat. Rev. Neurosci.,2012

2. Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase;Rafice;Biochem. Soc. Trans.,2009

3. The conversion of tryptophan to kynurenine in liver. I. The coupled tryptophan peroxidase-oxidase system forming formylkynurenine;Knox;J. Biol. Chem.,1950

4. Cerebral tryptophan-2,3-dioxygenase (pyrrolase) and its induction in rat brain;Gál;J. Neurochem.,1974

5. Identification of tryptophan 2,3-dioxygenase RNA in rodent brain;Haber;J. Neurochem.,1993

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