Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent

Author:

Manavathu Elias K.,Vazquez Jose A.,Chandrasekar Pranatharthi H.

Publisher

Elsevier BV

Subject

Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Medicine

Reference14 articles.

1. Manavathu EK, Alangaden GJ, Lerner SA. Isolation and characterization of itraconazole-resistant mutants of Aspergillus fumigatus. Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1995: American Society for Microbiology, Washington DC, USA, Abstract C, p. 570.

2. Azole-resistant Candida albicans: report of two cases of resistance to fluconazole and review;White;Clin Infect Dis,1994

3. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α-demethylase in Candida albicans;White;Antimicrob Agents Chemother,1997

4. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus;White;Antimicrob Agents Chemother,1997

5. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters;Sanglard;Antimicrob Agents Chemother,1995

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