Paclitaxel sensitizes homologous recombination-proficient ovarian cancer cells to PARP inhibitor via the CDK1/BRCA1 pathway

Author:

Yanaihara Nozomu,Yoshino Yuki,Noguchi Daito,Tabata Junya,Takenaka Masataka,Iida Yasushi,Saito Misato,Yanagida Satoshi,Iwamoto Masami,Kiyokawa Takako,Chiba Natsuko,Okamoto Aikou

Funder

Japan Society for the Promotion of Science

Terumo Foundation for Life Sciences and Arts

Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering

Publisher

Elsevier BV

Subject

Obstetrics and Gynecology,Oncology

Reference23 articles.

1. PARP inhibitors for ovarian cancer: current indications, future combinations, and novel assets in development to target DNA damage repair;Konstantinopoulos;Am. Soc. Clin. Oncol. Educ. Book.,2020

2. Veliparib with first-line chemotherapy and as maintenance therapy in ovarian cancer;Coleman;N. Engl. J. Med.,2019

3. Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer - an ancillary data analysis of the VELIA trial;Aghajanian;Gynecol. Oncol.,2022

4. BRCA1/ATF1-mediated transactivation is involved in resistance to PARP inhibitors and cisplatin;Endo;Cancer Res. Commun.,2021

5. Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency;Yoshino;Sci. Rep.,2019

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