Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine: identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns

Author:

Chung Woon-Gye,Roh Hyung-Keun,Kim Hwan-Mook,Cha Young-Nam

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference28 articles.

1. Evidence for the involvement of several cytochrome P-450 in the first steps of caffeine metabolism by human liver microsomes;Berthou;Drug Metab. Dispos.,1991

2. Human cytochrome P450PA(P4501A2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines;Butler;Proc. Natl. Acad. Sci. USA,1989

3. Determination of carcinogenesis arylamine N-oxidation phenotype in humans by analysis of caffeine urinary metabolites;Kadlubar,1990

4. Determination of CYP1A2 and NAT2 phenotypes in human population by analysis of caffeine urinary metabolites;Butler;Pharmacogenetics,1992

5. Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene;Nakajima;Cancer Epidemiol. Biomark. Prev.,1994

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