Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation

Author:

Ratra Gurpreet S,Powell Christopher J,Park B.Kevin,Maggs James L,Cottrell Suzanne

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference44 articles.

1. Pharmacological properties of N,N-dimethyl-N′-(a-pyridyl)-N′-(a-thenyl)-ethylenediamine hydrochloride (thenylene hydrochloride) a new antihistamine compound;Roth;Arch. Int. Pharmacodyn.,1948

2. Liver tumours induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride;Lijinsky;Science,1980

3. Effects of methapyrilene on rat hepatic xenobiotic enzymes and liver morphology;Graichen;Fundam. Appl. Toxicol.,1985

4. Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene;Ratra;Toxicol. Sci.,1998

5. Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial dysfunction and is prevented by the calcium channel blocker verapamil;Ratra;Toxicology,1998

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