Mono N-arylation of piperazine(III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate-Reference-Cited by-同舟云学术

Mono N-arylation of piperazine(III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate

Published:2002-04 Issue:18 Volume:43 Page:3359-3363
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Hepperle Michael,Eckert Jeffrey,Gala Dinesh,Shen Lan,Anderson Evans C,Goodman Andrew

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference14 articles.

1. Sequential mono-N-arylation of piperazine nitrogens. Part 1: A simplified method and its application to the preparation of a key N,N′-biaryl piperazine antifungal intermediate

2. Sequential mono-N-arylation of piperazine nitrogens. Part 2: The role of hydrogen bonding

3. Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones

4. Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592

5. Pd-catalyzed aminations of aryl triazolones: Effective synthesis of hydroxyitraconazole enantiomers

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