Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes

Author:

Long Alan,Baldwin Steven W

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference10 articles.

1. Preparation and evaluation of a cyclic acyl nitrone as a synthon for stereospecific α-amino acid synthesis

2. Enantioselective synthesis of .alpha.-amino acid derivatives via the stereoselective alkylation of a homochiral glycine enolate synthon

3. Synthesis of nitrones by methyltrioxorhenium catalyzed direct oxidation of secondary amines

4. Synthesis of Nitrones Using the Methyltrioxorhenium/Hydrogen Peroxide System

5. After our initial development work was completed, nitrone 2 was prepared by an alternative synthesis and several cycloaddition reactions were reported. (a) Tamura, O.; Gotanda, K.; Terashima, R.; Kikuchi, M.; Miyawaki, T.; Sakamoto, M. Chem. Commun. 1996, 1861; (b) Tamura, O.; Kuroki, T.; Sakai, Y.; Takizawa, J.; Yoshino, J.; Morita, Y.; Mita, N.; Gotanda, K.; Sakamoto, M. Tetrahedron Lett. 1999, 40, 895; (c) Tamura, O.; Gotanda, K.; Yoshino, J.; Mirita, Y.; Terashima, R.; Mayumi, K.; Miyaweaki, T.; Mita, N.; Yamashita, M.; Ishibashi, H.; Sakamoto, M. J. Org. Chem. 2000, 65, 8544–8551.

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