Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Author:

Gay Carl M.ORCID,Stewart C. AllisonORCID,Park Elizabeth M.,Diao Lixia,Groves Sarah M.ORCID,Heeke SimonORCID,Nabet Barzin Y.ORCID,Fujimoto Junya,Solis Luisa M.,Lu Wei,Xi Yuanxin,Cardnell Robert J.,Wang QiORCID,Fabbri Giulia,Cargill Kasey R.ORCID,Vokes Natalie I.,Ramkumar Kavya,Zhang Bingnan,Della Corte Carminia M.,Robson Paul,Swisher Stephen G.,Roth Jack A.,Glisson Bonnie S.,Shames David S.,Wistuba Ignacio I.,Wang JingORCID,Quaranta Vito,Minna JohnORCID,Heymach John V.,Byers Lauren Averett

Funder

U.S. Department of Defense

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference65 articles.

1. Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer;Allison Stewart;Oncotarget,2017

2. Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial;Antonia;Lancet Oncol.,2016

3. IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade;Ayers;J. Clin. Invest.,2017

4. Small cell lung carcinoma subtypes defined by ASCL1, NEUROD1, POU2F3 and YAP1: comprehensive immunohistochemical and histopathologic characterization;Baine;J. Thorac. Oncol. 12, 1823–1835,2020

5. Abstract 5037: targeting MICA with therapeutic antibodies for the treatment of cancer;Bonnafous;J. ImmunoTherapy Cancer,2013

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3