21 Single-Stranded DNA Binding Proteins

Author:

Kowalczykowski Stephen C.,Bear David G.,Von Hippel Peter H.

Publisher

Elsevier

Reference217 articles.

1. Recent excitement in the DNA replication problem

2. We note that such binding interactions (with either single- or double-stranded nucleic acids) comprise a central component of the general interaction of virtually all genome regulatory proteins (including repressors, polymerases, nucleases, gyrases, helicases, etc.) with nucleic acid lattices. Thus it is important to note that the theoretical and experimental considerations outlined in this section in terms of HDPs are general, and form, in exactly the same terms, a part of the description of all nucleic acid binding proteins.

3. RNA lattices are included in this discussion because they can serve as binding sites for autogenous regulatory interactions (at least for phage T4-coded gene 32 protein) and because they comprise an appreciable fraction of the nucleic acid composition of the cell, and thus may compete with the primary single-stranded DNA target sequences for free single-stranded binding protein.

4. DNA "melting" proteins. II. Effects of bacteriophage T4 gene 32-protein binding on the conformation and stability of nucleic acid structures.

5. Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids

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