Strengthening and accelerating SARS-CoV-2 vaccine safety surveillance through registered pre-approval rollout after challenge tests

Author:

Eyal Nir,Gerhard Tobias,Strom Brian L.ORCID

Funder

Wellcome Trust

Publisher

Elsevier BV

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Veterinary,General Immunology and Microbiology,Molecular Medicine

Reference29 articles.

1. Callaway E. Dozens to be deliberately infected with coronavirus in UK ‘human challenge’ trials. Nature. 2020. Epub 20 October. doi: 10.1038/d41586-020-02821-4.

2. Douglas AD, Hill AVS. Immunological considerations for SARS-CoV-2 human challenge studies. Nat Rev Immunol. 2020. Epub 21 October. doi: 10.1038/s41577-020-00472-0.

3. WHO Working Group for Guidance on Human Challenge Studies in COVID-19. Key criteria for the ethical acceptability of COVID-19 human challenge studies. Geneva: WHO, 2020 6 May. Report No.: Contract No.: WHO/2019-nCoV/Ethics_criteria/2020.1.

4. Britain first to infect healthy volunteers with coronavirus for study;Schwedes;DPA Int,2021

5. Human challenge trials of covid-19 vaccines still have much to teach us;Eyal;BMJ Opin,2021

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