Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity

Author:

Barton Kenneth N.,Paielli Dell,Zhang Yingshu,Koul Sweaty,Brown Stephen L.,Lu Mei,Seely John,Ho Kim Jae,Freytag Svend O.

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference33 articles.

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2. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in subjects with refractory head and neck cancer;Nemunaitis;J. Clin. Oncol,2001

3. Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in subjects with advanced head and neck cancer: a phase II trial;Nemunaitis;Cancer Res,2000

4. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in subjects with recurrent head and neck cancer;Khuri;Nat. Med,2000

5. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma;Hecht;Clin. Cancer Res,2003

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