Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells-Reference-Cited by-同舟云学术

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Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells

Published:2017-03 Issue:3 Volume:25 Page:580-592
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Diaconu Iulia,Ballard Brandon,Zhang Ming,Chen Yuhui,West John,Dotti Gianpietro,Savoldo Barbara

Funder

SCOR grant from the Leukemia and Lymphoma Society

Tier 2-Stimulus Award, Lineberger Comprehensive Cancer Center, University of North Carolina

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference41 articles.

1. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial;Lee;Lancet,2015

2. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia;Maude;Blood,2015

3. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia;Brentjens;Sci. Transl. Med.,2013

4. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor;Kochenderfer;J. Clin. Oncol.,2015

5. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety;Hoyos;Leukemia,2010

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