Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR)-Reference-Cited by-同舟云学术

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Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR)

Published:2003-06 Issue:11 Volume:13 Page:1865-1868
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Costantino Gabriele,Macchiarulo Antonio,Entrena-Guadix Antonio,Camaioni Emidio,Pellicciari Roberto

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

2. Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

3. The Steroid and Thyroid Hormone Receptor Superfamily

4. A canonical structure for the ligand-binding domain of nuclear receptors

5. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

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3. Semisynthetic bile acids: a new therapeutic option for metabolic syndrome;Pharmacological Research;2019-08

4. The Discovery of Obeticholic Acid (Ocaliva™): First-in-Class FXR Agonist;Successful Drug Discovery;2018-04-16

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