Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors-Reference-Cited by-同舟云学术

Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors

Published:2000-01 Issue:1 Volume:10 Page:1-4
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Soll Richard M.,Lu Tianobao,Tomczuk Bruce,Illig Carl R.,Fedde Cynthia,Eisennagel Stephen,Bone Roger,Murphy Larry,Spurlino John,Salemme F.Raymond

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. The therapeutic potential of novel anticoagulants

2. Small-molecule direct thrombin inhibitors

3. Thrombosis and Coagulation

4. In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors

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