p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas

Author:

Redman Anikó M,Johnson Jeffrey S,Dally Robert,Swartz Steve,Wild Hanno,Paulsen Holger,Caringal Yolanda,Gunn David,Renick Joel,Osterhout Martin,Kingery-Wood Jill,Smith Roger A,Lee Wendy,Dumas Jacques,Wilhelm Scott M,Housley Timothy J,Bhargava Ajay,Ranges Gerald E,Shrikhande Alka,Young Deborah,Bombara Michael,Scott William J

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Lee, J. C.; Laydon, J. T.; McDonnell, P. C.; Gallagher, T. F.; Kumar, S.; Green, D.; McNulty, D.; Blumenthal, M. J.; Heys, J. R.; Landvatter, S. W.; Stricker, J. E.; McLaughlin, M. M.; Siemens, I. R.; Fisher, S. M.; Livi, G. P.; White, J. R.; Adams, J. L.; Yound, P. R. Nature 1994, 372, 739. Han, J.; Lee, J.-D.; Bibbs, L.; Ulevitch, R. J. Science 1994, 265, 808.

2. Gallagher, T. F.; Fier-Thompson, S. M.; Garigipati, R. S.; Sorenson, M. E.; Smietana, J. M.; Lee, D.; Bender, P. E.; Lee, J. C.; Laydon, J. T.; Chabot-Fletcher, M. C.; Breton, J. J.; Adams, J. L. Bioorg. Med. Chem. Lett. 1995, 5, 1171. Boehm, J. C.; Smietana, J. M.; Sorenson, M. E.; Gallagher, T. F.; Sheldrake, P. L.; Bradbeer, J.; Badger, A. M.; Laydon, J. T.; Lee, J. C.; Hillegrass, L. M.; Griswold, D. E.; Breton, J. J.; Chabot-Fletcher, M. C.; Adams, J. L. J. Med. Chem. 1996, 39, 3929.

3. The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

4. For additional examples of urea-based p38 kinase inhibitors, see: (a) Dumas, J.; Sibley, R.; Riedl, B.; Monahan, M. K.; Lee, W.; Lowinger, T. B.; Redman, A. M.; Johnson, J. S.; Kingery-Wood, J.; Scott, W. J.; Smith, R. A.; Bobko, M.; Schoenleber, R.; Ranges, G. E.; Housley, T. J.; Bhargava, A.; Wilhelm, S. M.; Shrikhande, A. Bioorg. Med. Chem. Lett. 2000, 10, 2047. (b) Dumas, J.; Hatoum-Mokdad, H.; Sibley, R.; Riedl, B.; Monahan, M. K.; Lowinger, T. B.; Brennan, C. R.; Natero, R.; Turner, T.; Scott, W. J.; Redman, A. M.; Johnson, J. S.; Schoenleber, R.; Wilhelm, S. M.; Housley, T. J.; Ranges, G. E.; Bhargava, A.; Shrikhande, A. Bioorg. Med. Chem. Lett. 2000, 10, 2051.

5. The syntheses of 5-amino-3-t-butylisothiazole and 3-amino-5-t-butylisothiazole

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