Design, synthesis, and structure–activity relationship studies of ATP analogues as DNA gyrase inhibitors

Author:

Lübbers Thomas,Angehrn Peter,Gmünder Hans,Herzig Silvia,Kulhanek Josef

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. (a) Niccolai, D.; Tarsi, L.; Thomas, R. J. Chem. Comm. 1997, 2333. (b) Chu, D. T. W.; Plattner, J. J.; Katz, L. J. Med. Chem. 1996, 39, 3853.

2. DNA Gyrase: Structure and Function

3. (a) Geiwiz, J.; Götschi, E.; Hebeisen, P.; Link, H.; Lübbers, T. EP Patent 675122, 1995. (b) Goetschi, E.; Angehrn, P.; Gmuender, H.; Hebeisen, P.; Link, H.; Masciadri, R.; Nielsen, J. Pharmacol. Ther. 1993, 60, 367. (c) Goetschi, E.; Angehrn, P.; Gmuender, H.; Hebeisen, P.; Link, H.; Masciadri, R.; Reindl, P.; Ricklin, F. In Medicinal Chemistry: Today and Tomorrow. Proceedings of AIMECIS 95, Tokyo, September 1995; Yamazaki, M., Ed.; Blackwell Science Ltd.: Oxford, 1996; pp 263–270.

4. (a) Garrod, L. P.; Lambert, H. P.; O'Grady, F. In Antibiotic and Chemotherapy; 5th ed.; Churchill Livingstone: Edinburgh, 1981; pp 225–229. (b) Kawaguchi, H.; Tsukiura, M.; Okanishi, T; Miyaki, T.; Ohmori, K.; Fujisawa, K.; Koshiyama, J. J. Antibiot. 1965, 18, 1. (c) Linet, L.; Benazet, F.; Chapentie, Y.; Dubost, M.; Florent, J.; Nancy, D.; Preud’Homme, J.; Threlfall, T. L.; Vuillenain, B.; Wright, D. E.; Abraham, A.; Cartier, M.; De Chezelles, N.; Godard, C.; Theilleux, J. C.R. Acad. Sci. Ser. C. 1972, 275, 455.

5. Crystal structure of an N-terminal fragment of the DNA gyrase B protein

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