Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin

Author:

Yokoyama Masayuki,Okano Teruo,Sakurai Yasuhisa,Kataoka Kazunori

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference19 articles.

1. Preparation of micelle-forming polymer-drug conjugates;Yokoyama;Bioconjugate Chem.,1992

2. Block copolymers as drug carriers;Yokoyama;Crit. Rev. Ther. Drug Carrier Systems,1992

3. Polymeric micelles for drug delivery;Kataoka;J. Contr. Rel.,1993

4. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer;Yokoyama;Cancer Res.,1990

5. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood;Yokoyama;Cancer Res.,1991

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