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Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors

  • Published:2020-08 Issue:15 Volume:28 Page:115597
  • ISSN:0968-0896
  • Container-title:Bioorganic & Medicinal Chemistry
  • language:en
  • Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Silva Taynara L.,dos Santos Deborah A.,de Jesus Hugo C.R.,Brömme Dieter,Fernandes João B.,Paixão Marcio W.,Corrêa Arlene G.,Vieira Paulo C.

Funder

FAPESP

CAPES

CNPq

Canadian Institutes of Health Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference33 articles.

1. Papain-like cysteine proteases;Brömme;Curr Protoc Protein Sci,2001

2. Cysteine cathepsins: from structure, function and regulation to new frontiers;Turk;BBA,2012

3. Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design;Lecaille;Chem Rev,2002

4. Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib;Law;Biochem J,2017

5. Inhibition of cathepsin K for treatment of osteoporosis;Boonen;Curr Osteoporos Rep,2012

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