Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis-Reference-Cited by-同舟云学术

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis

Published:2019-12 Issue:23 Volume:27 Page:115125
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Xiang Weiguo,Dekhne Aamod,Doshi Arpit,O'Connor Carrie,Hou Zhanjun,Matherly Larry H.,Gangjee Aleem

Funder

National Institutes of Health

Eunice and Milton Ring Endowed Chair for Cancer Research

Duquesne University Adrian Van Kaam Chair in Scholarly Excellence

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference51 articles.

1. The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer;Matherly;Drug Metab Dispos,2014

2. The antifolates;Visentin;Hematol Oncol Clin N,2012

3. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy;Matherly;Cancer Metastasis Rev,2007

4. Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter;Kugel Desmoulin;Mol Pharmacol,2012

5. The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer;Matherly;Cancer Chemother Pharmacol,2018

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