Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

Author:

Poon Kirsten Achilles,Flagella Kelly,Beyer Joseph,Tibbitts Jay,Kaur Surinder,Saad Ola,Yi Joo-Hee,Girish Sandhya,Dybdal Noel,Reynolds Theresa

Funder

Genentech

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference57 articles.

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3. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer;Blackwell;J. Clin. Oncol.,2010

4. Drugs to enhance the therapeutic potency of anticancer antibodies: antibody-drug conjugates as tumor-activated prodrugs;Blättler,2001

5. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy;Burris;J. Clin. Oncol.,2011

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