Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author:

Coutts Shelagh B,Ankolekar Sandeep,Appireddy Ramana,Arenillas Juan F,Assis Zarina,Bailey Peter,Barber Philip A,Bazan Rodrigo,Buck Brian H,Butcher Ken S,Camden Marie-Christine,Campbell Bruce C V,Casaubon Leanne K,Catanese Luciana,Chatterjee Kausik,Choi Philip M C,Clarke Brian,Dowlatshahi Dar,Ferrari Julia,Field Thalia S,Ganesh Aravind,Ghia Darshan,Goyal Mayank,Greisenegger Stefan,Halse Omid,Horn Mackenzie,Hunter Gary,Imoukhuede Oje,Kelly Peter J,Kennedy James,Kenney Carol,Kleinig Timothy J,Krishnan Kailash,Lima Fabricio,Mandzia Jennifer L,Marko Martha,Martins Sheila O,Medvedev George,Menon Bijoy K,Mishra Sachin M,Molina Carlos,Moussaddy Aimen,Muir Keith W,Parsons Mark W,Penn Andrew M W,Pille Arthur,Pontes-Neto Octávio M,Roffe Christine,Serena Joaquin,Simister Robert,Singh Nishita,Spratt Neil,Strbian Daniel,Tham Carol H,Wiggam M Ivan,Williams David J,Willmot Mark R,Wu Teddy,Yu Amy Y X,Zachariah George,Zafar Atif,Zerna Charlotte,Hill Michael D,Salluzzi Marina,Blenkin Nicole,Dueck Ashley,Doram Craig,Zhang Qiao,Kenney Carol,Ryckborst Karla,Bohn Shelly,Collier Quentin,Taylor Frances,Lethebe B. Cord,Jambula Anitha,Sage Kayla,Toussaint Lana,Save Supryia,Lee Jaclyn,Laham N,Sultan A.A.,Deepak A.,Sitaram A.,Demchuk Andrew M.,Lockey A.,Micielli A.,Wadhwa A.,Arabambi B.,Graham B.,Bogiatzi Chrysi,Doshi Darshan,Chakraborty D.,Kim Diana,Vasquez D,Singh D,Tse Dominic,Harrison E.,Smith E.E.,Teleg E.,Klourfeld E.,Klein G.,Sebastian I.A.,Evans J,Hegedus J,Kromm J,Lin K,Ignacio K,Ghavami Kimia,Ismail M.,Moores M.,Panzini M.A.,Boyko M.,Almekhlafi M.A.,Newcommon Nancy,Maraj N.,Imoukhuede O.,Volny O.,Stys Peter,Couillard Phillipe,Ojha P.,Eswaradass P.,Joundi Raed,Singh R.,Asuncion R.M.,Muir R.T.,Dey S.,Mansoor S.,Wasyliw S.,Nagendra S.,Hu Sherry,Althubait S.,Chen S.,Bal S.,Van Gaal Stephen,Peters Steven,Ray Sucharita,Chaturvedi S.,Subramaniam Suresh,Fu Vivian,Villaluna K.,Maclean G.,King-Azote P.,Ma C.,Plecash A.,Murphy C.,Gorman J.,Wilson L.,Zhou L.,Benevente O.,Teal P.,Yip S.,Mann S.,Dewar B.,Demetroff M.,Shamloul R.,Beardshaw R.,Roberts S.,Blaquiere D.,Stotts G.,Shamy M.,Bereznyakova O.,Fahed R.,Alesefir W.,Lavoie Suzy,Hache A.,Collard K,Mackey A.,Gosselin-Lefebvre S.,Verreault S.,Beauchamp B.,Lambourn L.,Khaw A.,Mai L.,Sposato L.,Bres Bullrich M.,Azarpazhooh R.,Fridman S.,Kapoor A.,Southwell A.,Bardi E.,Fatakdawala I.,Kamra M,Lopes K.,Popel N.,Norouzi V.,Liu A.,Liddy A.M.,Ghoari B.,Hawkes C.,Enriquez C.A.,Gladstone D.J.,Manosalva Alzate H.A.,Khosravani H.,Hopyan J.J.,Sivakumar K.,Son M.,Boulos M.I.,Hamind M.A.,Swartz R.H.,Murphy R.,Reiter S.,Fitzpatrick T.,Bhandari V.,Good J.,Penn M.,Naylor M.,Frost S.,Cayley A.,Akthar F.,Williams J.,Kalman L.,Crellin L.,Wiegner R.,Singh R.S.,Stewart T.,To W.,Singh S.,Pikula A.,Jaigobin C.,Carpani F.,Silver F.,Janssen H.,Schaafsma J.,del Campo M.,Alskaini M.,Rajendram P.,Fairall P.,Granfield B.,Crawford D.,Jabs J.,White L.,Sivakumar L.,Piquette L.,Nguyen T.,Nomani A.,Wagner A.,Alrohimi A.,Butt A.,D'Souza A.,Gajurel B.,Vekhande C.,Kamble H.,Kalashyan H.,Lloret M.,Benguzzi M.,Arsalan N.,Ishaque N.,Ashayeriahmadabad R.,Samiento R.,Hosseini S.,Kazi S.,Das S.,Sugumar T.,Selchen D.,Kostyrko P.,Muccilli A.,Saposnik A.G.,Vandervelde C.,Ratnayake K.,McMillan S.,Katsanos A.,Shoamanesh A.,Sahlas D.J.,Naidoo V.,Todorov V.,Toma H.,Brar J.,Lee J.,Horton M.,Chen S.,Shand E.,Weatherby S.,Jin A.,Durafourt B.,Jalini S.,Gardner A.,Tyson C.,Junk E.,Foster K.,Bolt K.,Sylvain N.,Maley S.,Urroz L.,Peeling L.,Kelly M.,Whelan R.,Cooley R.,Teitelbaum J.,Boutayeb A.,Moore A.,Cole E.,Waxman L.,Ben-Amor N.,Sanchez R.,Khalil S.,Nehme A.,Legault C.,Tampieri D.,Ehrensperger E.,Vieira L.,Cortes M.,Angle M.,Hannouche M.,Badawy M.,Werner K.,Wieszmuellner S.,Langer A.,Gisold A.,Zach H.,Rommer P.,Macher S.,Blechinger S.,Marik W.,Series W.,Baumgartinger M.,Krebs S.,Koski J.,Eirola S.,Ivanoff T.,Erakanto A.,Kupari L.,Sibolt G.,Panula J.,Tomppo L.,Tiainen M.,Ahlstrom M.,Martinez Majander N.,Suomalainen O.,Raty S.,Levi C.,Kerr E.,Allen J.,Kaauwai L.P.,Belevski L.,Russell M.,Ormond S.,Chew A.,Loiselle A.,Royan A.,Hughes B.,Garcia Esperon C.,Pepper E.,Miteff F.,He J.,Lycett M.,Min M.,Murray N.,Pavey N.,Starling de Barros R.,Gangadharan S.,Dunkerton S.,Waller S.,Canento Sanchez T.,Wellings T.,Edmonds G.,Whittaker K.A.,Ewing M.,Lee P.,Singkang R.,McDonald A.,Dos Santos A.,Shin C.,Jackson D.,Tsoleridis J.,Fisicchia L.,Parsons N.,Shenoy N.,Smith S.,Sharobeam A.,Balabanski A.,Park A.,Williams C.,Pavlin-Premri D.,Rodrigues E.,Alemseged F.,Ng F.,Zhao H.,Beharry J.,Ng J.L.,Williamson J.,Wong J.Z.W.,Li K.,Kwan M.K.,Valente M.,Yassi N.,Cooley R.,Yogendrakumar V.,McNamara B.,Buchanan C.,McCarthy C.,Thomas G.,Stephens K.,Chung M.,Chung M.F.,Tang M.,Busch T.,Frost T.,Lee R.,Stuart N.,Pachani N.,Menon A.,Borojevic B.,Linton C.M.,Garcia G.,Callaly E.P.,Dewey H.,Liu J.,Chen J.,Wong J.,Nowak K.,To K.,Lizak N.S.,Bhalala O.,Park P.,Tan P.,Martins R.,Cody R.,Forbes R.,Chen S.K.,Ooi S.,Tu S.,Dang Y.L.,Ling Z.,Cranefield J.,Drew R.,Tan A.,Kurunawai C.,Harvey J.,Mahadevan J.J.,Cagi L.,Palanikumar L.,Chia L.N.,Goh R.,El-Masri S.,Urbi B.,Rapier C.,Berrill H.,McEvoy H.,Dunning R.,Kuriakose S.,Chad T.,Sapaen V.,Sabet A.,Shah D.,Yeow D.,Lilley K.,Ward K.,Mozhy Mahizhnan M.,Tan M.,Lynch C.,Coveney S.,Tobin K.,McCabe J.,Marnane M.,Murphy S.,Large M.,Moynihan B.,Boyle K.,Sanjuan E.,Sanchis M.,Boned S.,Pancorbo O.,Sala V.,Garcia L.,Garcia-Tornel A.,Juega J.,Pagola J.,Santana K.,Requena M.,Muchada M.,Olive M.,Lozano P.J.,Rubiera M.,Deck M.,Rodriguez N.,Gomez B.,Reyes Munoz F.J.,Gomez A.S.,Sanz A.C.,Garcia E.C.,Penacoba G.,Ramos M.E.,de Lera Alfonso M.,Feliu A,Pardo L.,Ramirez P.,Murillo A.,Lopez Dominguez D.,Rodriguez J.,Terceno Izaga M.,Reina M.,Viturro S.B.,Bojaryn U.,Vera Monge V.A.,Silva Blas Y.,R Siew R.,Agustin S J,Seet C.,Tianming T.,d'Emden A.,Murray A.,Welch A.,Hatherley K.,Day N.,Smith W.,MacRae E.,Mitchell E.S.,Mahmood A.,Elliot J.,Neilson S.,Biswas V.,Brown C.,Lewis A.,Ashton A.,Werring D.,Perry R.,Muhammad R.,Lee Y.C.,Black A.,Robinson A.,Williams A.,Banaras A.,Cahoy C.,Raingold G.,Marinescu M.,Atang N.,Bason N.,Francia N.,Obarey S.,Feerick S.,Joseph J.,Schulz U.,Irons R.,Benjamin J.,Quinn L.,Jhoots M.,Teal R.,Ford G.,Harston G.,Bains H.,Gbinigie I.,Mathieson P.,Irons R.,Sim C.H.,Hayter E.,Kennedy K.,Binnie L.,Priestley N.,Williams R.,Ghatala R.,Stratton S.,Blight A.,Zhang L.,Davies A.,Duffy H.,Roberts J.,Homer J.,Roberts K.,Dodd K.,Cawley K.,Martin M.,Leason S.,Cotgreave S.,Taylor T.,Nallasivan A.,Haider S.,Chakraborty T.,Webster T.,Gil A.,Martin B.,Joseph B.,Cabrera C.,Jose D.,Man J.,Aquino J.,Sebastian S.,Osterdahl M.,Kwan M.,Matthew M.,Ike N.,Bello P.,Wilding P.,Fuentes R.,Shah R.,Mashate S.,Patel T.,Nwanguma U.,Dave V.,Haber A.,Lee A.,O'Sullivan A.,Drumm B.,Dawson A.C.,Matar T.,Biswas V.,Roberts D.,Taylor E.,Rounis E.,El-Masry A.,O'Hare C.,Kalladka D.,Jamil S.,Auger S.,Raha O.,Evans M.,Vonberg F.,Kalam S.,Ali Sheikh A.,Jenkins I.H.,George J.,Kwan J.,Blagojevic J.,Saeed M.,Haji-Coll M.,Tsuda M.,Sayed M.,Winterkron N.,Thanbirajah N.,Vittay O.,Karim R.,Smail R.C.,Gauhar S.,Elmamoun S.,Malani S.,Pralhad Kelavkar S.,Hiden J.,Ferdinand P.,Sanyal R.,Varquez R.,Smith B.,Okechukwu C.,Fox E.,Collins E.,Courtney K.,Tauro S.,Patterson C.,McShane D.,Kerr E.,Roberts G.,McIImoyle J.,McGuire K.,Fearon P.,Gordon P.,Isaacs K.,Lucas K.,Smith L.,Dews L.,Bates M.,Lawrence S.,Heeley S.,Patel V.,Chin Y.M.,Sims D.,Littleton E.,Khaira J.,Nadar K.,Kieliszkowska A.,Sari B.,Domingos Belo C.,Smith E.,Manolo E.Y.,Aeron-Thomas J.,Doheny M.,Garcia Pardo M.,Recaman M.,Tibajia M.C.,Aissa M.,Mah Y.,Yu T.,Patel V.,Meenakshisundaram S.,Heller S.,Alsukhni R.,Williams O.,Farag M.,Benger M.,Engineer A.,Aissa M.,Bayhonan S.,Conway S.,Bhalla A.,Nouvakis D.,Theochari E.,Boyle F.,Teo J.,King-Robson J.,Law K.Y.,Sztriha L.,Ismail M.,McGovern A.,Day D.,Mitchell-Douglas J.,Francis J.,Iqbal A.,Punjabivaryani P.,Anonuevo Reyes J.,Anonuevo Reyes M.,Pauls M.,Buch A.,Hedstrom A.,Hutchinson C.,Kirkland C.,Newham J.,Wilkes G.,Fleming L.,Fleck N.,Franca A.,Chwal B.,Oldoni C.,Mantovani G.,Noll G.,Zanella L.,Soma M.,Secchi T.,Borelli W.,Rimoli B.P.,da Cunha Silva G.H.,Machado Galvao Mondin L.A.,Barbosa Cerantola R.,Imthon A.K.,Esaki A.S.,Camilo M.,Vincenzi O.C.,ds Cruz R.R.,Morillos M.B.,Riccioppa Rodrigues G.G.,Santos Ferreira K.,Pazini A.M.,Pena Pereira M.A.,de Albuquerque A.L.A.,Massote Fontanini C.E.,Matinez Rubio C.F.,dos Santos D.T.,Dias F.A.,Alves F.F.A.,Milani C.,Pegorer Santos B.,Winckler F.,De Souza J.T.,Bonome L.A.M.,Cury Silva V.A.,Teodoro R.S.,Modolo G.P.,Ferreira N.C.,Barbosa dos Santos D.F.,dos Santos Moreira J.C.,Cruz Guedes de Morais A.B.,Vieira J.,Mendes G.,de Queiroz J.P.

Funder

Heart and Stroke Foundation of Canada

British Heart Foundation

Canadian Institutes of Health Research

Publisher

Elsevier BV

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