1. Department of Clinical Pharmacology; University Medical Center Groningen; Antonius Deusinglaan 1, 9713 AV Groningen The Netherlands
2. Trial Coordination Centre (TCC); University Medical Center Groningen; P.O. Box 30.001, 9700 RB Groningen The Netherlands
3. Department of Medicine; Sahlgrenska University Hospital/Ostra; S-416 85 Goteborg Sweden