Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block

Author:

Clancy Robert M.,Markham Androo J.,Reed Joanne H.,Blumenberg Miroslav,Halushka Marc K.,Buyon Jill P.

Funder

National Institutes of Health Merit Award

the Research Registry for Neonatal Lupus

Lupus Foundation of America Lifeline grant

the National Institutes of Health

Australian National Health and Medical Research Council

Publisher

Elsevier BV

Subject

Immunology,Immunology and Allergy

Reference35 articles.

1. Neonatal lupus;Buyon,2011

2. Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block;Clancy;Arthritis Rheum.,2004

3. Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus;Llanos;Rheumatol. Oxf.,2012

4. The subcellular distribution of an RNA quality control protein, the Ro autoantigen, is regulated by noncoding Y RNA binding;Sim;Mol. Biol. Cell,2009

5. A Point Mutation in the SSA/Ro60 autoantigen which prevents Y RNA Binding attenuates a requisite signal for cell surface expression and TLR-dependent inflammation. [abstract];Reed;Arthritis Rheum.,2011

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