Integration of in vitro biorelevant dissolution and in silico PBPK model of carvedilol to predict bioequivalence of oral drug products

Author:

Ibarra ManuelORCID,Valiante Cristian,Sopeña Patricia,Schiavo Alejandra,Lorier Marianela,Vázquez Marta,Fagiolino Pietro

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference34 articles.

1. Carvedilol Pharmagenus Comprimidos EFG. Resumen del Estudio de Bioequivalencia;AMNEAL PHARMA SPAIN,2000

2. Carvedilol-liposome interaction: evidence for strong association with the hydrophobic region of the lipid bilayers;Cheng;Biochim. Biophys. Acta Biomembr.,1996

3. Assessment of bioequivalence of weak base formulations under various dosing conditions using physiologically based pharmacokinetic simulations in virtual populations. Case examples: ketoconazole and posaconazole;Cristofoletti;J. Pharm. Sci.,2017

4. Mechanism of the vasodilatory effect of carvedilol in normal volunteers: a comparison with labetalol;Cubeddu;J. Cardiovasc. Pharmacol.,1987

5. Virtual bioequivalence for achlorhydric subjects: the use of PBPK modelling to assess the formulation-dependent effect of achlorhydria;Doki;Eur. J. Pharm. Sci.,2017

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