A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects

Author:

Yang Xin-Mei,Yang Yang,Yao Bu-Fan,Ye Pan-Pan,Xu Yan,Peng Shao-Ping,Yang Yu-Mei,Shu Pan,Li Pei-Jin,Li Shan,Hu Hong-Lin,Li Qian,Song Lin-Lin,Chen Ke-Guang,Zhou Hai-Yan,Zhang Ye-Hui,Zhao Fu-Rong,Tang Bo-Hao,Zhang Wei,Zhang Xin-Fang,Fu Shu-Meng,Hao Guo-Xiang,Zheng Yi,Shen Jing-Shan,Xu Ye-Chun,Jiang Xiang-Rui,Zhang Lei-Ke,Tang Ren-Hong,Zhao WeiORCID

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference18 articles.

1. Emergency Use Authorization (EUA) For Paxlovid (Niematrelvir Tablets Co-Packaged With Ritonavir Tablets),2021

2. World medical association declaration of helsinki ethical principles for medical research involving human subjects;JAMA,2013

3. CDE, 2020. Technical guidelines for population pharmacokinetic research. https://www.cde.org.cn/main/news/viewInfoCommon/b3e8205a4749caa0264414514cdf45ac (accessed 20 Jul 2023).

4. CDE, 2005. Technical guidelines for clinical pharmacokinetic research of chemical drugs. https://www.cde.org.cn/zdyz/domesticinfopage?zdyzIdCODE=4247ffceca57f2b47aa0f67a3fdc7c43 (accessed 20 Jul 2023).

5. Disposition of nirmatrelvir, an orally bioavailable inhibitor of SARS-CoV-2 3C-like protease, across animals and humans;Eng;Drug Metab. Dispos.,2022

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