Acyclovir prodrug for the intestinal di/tri-peptide transporter PEPT1: comparison of in vivo bioavailability in rats and transport in Caco-2 cells

Author:

Thomsen Anne Engelbrecht,Christensen Michael Søberg,Bagger Morten Aavad,Steffansen Bente

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference19 articles.

1. Conjugation of di-peptide to fluorescent dyes enhances its affinity for a di-peptide transporter (PEPT1) in human intestinal Caco-2 cells;Abe;Bioconjug. Chem.,1999

2. Metabolism of intravenously administered di-peptides in rats: effects on amino acid pools, glucose concentration and insulin and glucagon secretion;Adibi;Clin. Sci. Mol. Med.,1977

3. How to make drugs orally active: a substrate template for peptide transporter PepT1;Bailey;Angew. Chem. Int. Ed.,2000

4. Amino acid ester prodrugs of acyclovir;Beauchamp;Antivir. Chem. Chemother.,1992

5. Metabolic disposition of the acyclovir prodrug valaciclovir in the rat;Burnette;Drug Metab. Dispos.,1994

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