A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer

Author:

Gupta ShantanuORCID,Silveira Daner A.,Piedade Gabriel P.S.,Ostrowski Miguel P.,Mombach José Carlos M.ORCID,Hashimoto Ronaldo F.ORCID

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

FAPESP

Publisher

Elsevier BV

Subject

Biochemistry (medical),Genetics,Molecular Biology,Biochemistry

Reference57 articles.

1. Increased MALAT1 expression contributes to cisplatin resistance in non-small cell lung cancer;Cui;Oncol. Lett.,2018

2. miR-145-5p targets Sp1 in non-small cell lung cancer cells and links to BMI1 induced pemetrexed resistance and epithelial–mesenchymal transition;Chang;Int. J. Mol. Sci.,2022

3. Sp1-mediated transcriptional regulation of MALAT1 plays a critical role in tumor;Li;J. Cancer Res. Clin. Oncol.,2015

4. miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc;Chen;J. Exp. Clin. Cancer Res.,2010

5. miR-145 suppresses the proliferation, invasion and migration of NSCLC cells by regulating the BAX/BCL-2 ratio and the caspase-3 cascade;Pan;Oncol. Lett.,2018

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