5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent regulator of cholesterol metabolism: occurrence in rat skin.

Author:

Emmons G T,St Pyrek J,Dam R,Martin M,Kudo K,Schroepfer G J

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Biochemistry

Reference65 articles.

1. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols;Schroepfer;J. Biol. Chem.,1977

2. 5α-Cholest-8(14)-en-3β-ol-15-one, a potent inhibitor of sterol synthesis, reduces the levels of activity of enzymes involved in the synthesis and reduction of 3-hydroxy-3-methylglutaryl coenzyme A in CHO-K1 cells;Miller;Biochem. Int.,1980

3. 14a-Ethyl-5α- cholest-7-ene-3β,15α-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells;Pinkerton;J. Biol. Chem.,1982

4. Inhibitors of sterol synthesis. Dietary administration of 5α-cholest-8(14)-en-3β- ol-15-one inhibits the intestinal absorption of cholesterol;Schroepfer;Biochem.- Biophys. Res. Commun.,1987

5. 5α-Cholest-8(14)-en-3β- ol-15-one. A competitive substrate for acyl coenzyme A:cholesterol acyl transferase;Miller;Biochem. Biophys. Res. Commun.,1987

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