Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics

Author:

Sigman Lucas,Sánchez Verónica Muriel,Turjanski Adrián Gustavo

Publisher

Elsevier BV

Subject

Materials Chemistry,Computer Graphics and Computer-Aided Design,Physical and Theoretical Chemistry,Spectroscopy

Reference37 articles.

1. Specific chemotherapy of Chagas’ disease: controversies and advances;Urbina;Trends Parasitol.,2003

2. American trypanosomiasis (Chagas’ disease) and the role of molecular epidemiology in guiding control strategies;Miles;BMJ,2003

3. American trypanosomiasis (Chagas’ disease)—a tropical disease now in the United States;Kirchhoff;N. Engl. J. Med.,1993

4. Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs;Urbina;J. Biol. Chem.,1999

5. Structure–activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates;Dunford;J. Pharmacol. Exp. Ther.,2001

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