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Dust fall PM2.5-induced lung inflammation in rats is associated with hypermethylation of the IFN-γ gene promoter via the PI3K-Akt-DNMT3b pathway

  • Published:2022-10 Issue: Volume:95 Page:103942
  • ISSN:1382-6689
  • Container-title:Environmental Toxicology and Pharmacology
  • language:en
  • Short-container-title:Environmental Toxicology and Pharmacology

Author:

Bai Jun,Wang Hailan,Yang Siyu,Lu Ji,Li Chenwen,Sun Yaochuan,Huo Tingting,Deng Jianjun,Zhang Qingbi

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,General Medicine

Reference45 articles.

1. Unmasking the lung cancer epigenome;Belinsky;Annu. Rev. Physiol.,2015

2. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments;Bellavia;J. Am. Heart Assoc.,2013

3. Epigenetic biomarkers for risk assessment of particulate matter associated lung cancer;Bhargava;Curr. Drug Targets,2018

4. DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma;Brand;J. Allergy Clin. Immunol.,2012

5. MiR-140-5p/TLR4 /NF-κB signaling pathway: Crucial role in inflammatory response in 16HBE cells induced by dustfall PM(2.5);Chen;Ecotoxicol. Environ. Saf.,2021

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