Author:
Garriga Marina,Wium-Andersen Marie K,Wium-Andersen Ida K,Nordentoft Merete,Osler Merete
Abstract
Abstract
Background:
Birth dimensions have been associated with increased risk of both,
severe mental illness and type 2 diabetes in adulthood, however, any
influence on their co-occurrence has never been examined. This cohort
study examine whether birth weight/ponderal index explain or modify the
later association between severe mental illness and risk of type 2
diabetes.
Methods:
The Metropolit cohort included 10,863 Danish men born in 1953 with
information from age at conscription (between1971-84) until February
15th, 2018. Severe mental illness was defined
as the exposure and information was retrieved from the national Danish
health registries. Information on type 2 diabetes diagnosis or oral
antidiabetic prescriptions was also obtained, as they were the outcome
of interest. Information on birth weight/ponderal index was available
from birth certificates. Cox proportional hazards regression models were
used to estimate the associations and interactions were tested.
Results:
After 47.1 years of follow-up, 848 (7.8%) and 1320 (12.2%) men
developed a severe mental illness or diabetes, respectively. Men with
severe mental illness presented higher risk of subsequent diabetes (HR =
1.92; 95%CI, 1.61–2.30). This association was stronger in severe mental
ill men with low birth weight (HR = 3.58; 95%CI, 2.11–6.07), than in
those normal birth weight (HR = 1.79; 95%CI, 1.45–2.20). This effect
modification was most evident for men diagnosed with
schizophrenia.
Conclusions:
Birth information on birth weight/ponderal index could be of
interest in diabetes screening on severe mental ill populations
(especially in schizophrenia) since they might play a critical role in
the increased risk of type 2 diabetes following severe mental
illness.
Funder
Spanish Ministry of Economy and Competitiveness
Instituto de Salud Carlos III
FEDER
Centro de Investigación Biomédica en Red de Salud Mental
Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement
CERCA Programme / Generalitat de Catalunya
Lundbeck Foundation
Jascha Foundation
Danish health Insurance Fund
Danish heart Association
Danish Fund for Independendt Research
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health
Cited by
9 articles.
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