Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

Author:

Jun Gyungah R.12,Chung Jaeyoon2,Mez Jesse3,Barber Robert4,Beecham Gary W.5,Bennett David A.6,Buxbaum Joseph D.789,Byrd Goldie S.10,Carrasquillo Minerva M.11,Crane Paul K.12,Cruchaga Carlos1314,De Jager Philip1516,Ertekin‐Taner Nilufer11,Evans Denis17,Fallin M. Danielle18,Foroud Tatiana M.19,Friedland Robert P.20,Goate Alison M.7,Graff‐Radford Neill R.11,Hendrie Hugh2122,Hall Kathleen S.2223,Hamilton‐Nelson Kara L.5,Inzelberg Rivka24,Kamboh M. Ilyas25,Kauwe John S.K.26,Kukull Walter A.2728,Kunkle Brian W.5,Kuwano Ryozo29,Larson Eric B.1630,Logue Mark W.2631,Manly Jennifer J.3233,Martin Eden R.5,Montine Thomas J.34,Mukherjee Shubhabrata12,Naj Adam35,Reiman Eric M.36373839,Reitz Christiane404142,Sherva Richard2,St. George‐Hyslop Peter H.4344,Thornton Timothy12,Younkin Steven G.11,Vardarajan Badri N.323340,Wang Li‐San36,Wendlund Jens R.45,Winslow Ashley R.45,Adams Perrie M.12345,Albert Marilyn S.12345,Albin Roger L.12345,Apostolova Liana G.12345,Arnold Steven E.12345,Asthana Sanjay12345,Atwood Craig S.12345,Barmada Michjael M.12345,Barnes Lisa L.12345,Beach Thomas G.12345,Becker James T.12345,Bigio Eileen H.12345,Bird Thomas D.12345,Blacker Deborah12345,Boeve Bradley F.12345,Bowen James D.12345,Boxer Adam12345,Burke James R.12345,Cairns Nigel J.12345,Cao Chuanhai12345,Carlson Chris S.12345,Carlsson Cynthia M.12345,Carney Regina M.12345,Carrasquillo Minerva M.12345,Carroll Steven L.12345,Chui Helena C.12345,Clark David G.12345,Corneveaux Jason12345,Cribbs David H.12345,Crocco Elizabeth A.12345,Cruchaga Carlos12345,De Jager Philip L.12345,DeCarli Charles12345,DeKosky Steven T.12345,Demirci F. Yesim12345,Dick Malcolm12345,Dickson Dennis W.12345,Doody Rachelle S.12345,Duara Ranjan12345,Ertekin‐Taner Nilufer12345,Faber Kelley M.12345,Fairchild Thomas J.12345,Fallon Kenneth B.12345,Farlow Martin R.12345,Ferris Steven12345,Frosch Matthew P.12345,Galasko Douglas R.12345,Gearing Marla12345,Geschwind Daniel H.12345,Ghetti Bernardino12345,Gilbert John R.12345,Glass Jonathan D.12345,Graff‐Radford Neill R.12345,Green Robert C.12345,Growdon John H.12345,Hakonarson Hakon12345,Hamilton Ronald L.12345,Hardy John12345,Harrell Lindy E.12345,Head Elizabeth12345,Honig Lawrence S.12345,Huebinger Ryan M.12345,Huentelman Matthew J.12345,Hulette Christine M.12345,Hyman Bradley T.12345,Jarvik Gail P.12345,Jicha Gregory A.12345,Jin Lee‐Way12345,Karydas Anna12345,Kauwe John S.K.12345,Kaye Jeffrey A.12345,Kim Ronald12345,Koo Edward H.12345,Kowall Neil W.12345,Kramer Joel H.12345,LaFerla Frank M.12345,Lah James J.12345,Leverenz James B.12345,Levey Allan I.12345,Li Ge12345,Lieberman Andrew P.12345,Lin Chiao‐Feng12345,Lopez Oscar L.12345,Lyketsos Constantine G.12345,Mack Wendy J.12345,Marson Daniel C.12345,Martiniuk Frank12345,Mash Deborah C.12345,Masliah Eliezer12345,McCormick Wayne C.12345,McCurry Susan M.12345,McDavid Andrew N.12345,McKee Ann C.12345,Mesulam Marsel12345,Miller Bruce L.12345,Miller Carol A.12345,Miller Joshua W.12345,Morris John C.12345,Mukherjee Shubhabrata12345,Murrell Jill R.12345,Myers Amanda J.12345,O'Bryant Sid12345,Olichney John M.12345,Pankratz Vernon S.12345,Parisi Joseph E.12345,Partch Amanda12345,Paulson Henry L.12345,Perry William12345,Peskind Elaine12345,Petersen Ronald C.12345,Pierce Aimee12345,Poon Wayne W.12345,Potter Huntington12345,Quinn Joseph F.12345,Raj Ashok12345,Raskind Murray12345,Reisberg Barry12345,Reisch Joan S.12345,Reitz Christiane12345,Ringman John M.12345,Roberson Erik D.12345,Rogaeva Ekaterina12345,Rosen Howard J.12345,Rosenberg Roger N.12345,Royall Donald R.12345,Sager Mark A.12345,Sano Mary12345,Saykin Andrew J.12345,Schneider Julie A.12345,Schneider Lon S.12345,Seeley William W.12345,Smith Amanda G.12345,Sonnen Joshua A.12345,Spina Salvatore12345,Stern Robert A.12345,Tanzi Rudolph E.12345,Thornton‐Wells Tricia A.12345,Trojanowski John Q.12345,Troncoso Juan C.12345,Tsuang Debby W.12345,Van Deerlin Vivianna M.12345,Van Eldik Linda J.12345,Vardarajan Badri N.12345,Vinters Harry V.12345,Vonsattel Jean Paul12345,Weintraub Sandra12345,Welsh‐Bohmer Kathleen A.12345,Williamson Jennifer12345,Wishnek Sarah12345,Woltjer Randall L.12345,Wright Clinton B.12345,Wu Chuang‐Kuo12345,Yu Chang‐En12345,Yu Lei12345,Zhang Xiaoling12345,Haines Jonathan46,Mayeux Richard3233404142,Pericak‐Vance Margaret A.5,Schellenberg Gerard36,Lunetta Kathryn L.47,Farrer Lindsay A.23474849,

Affiliation:

1. Neurogenetics and Integrated Genomics Andover Innovative Medicines Institute, Eisai Inc Andover MA USA

2. Department of Medicine (Biomedical Genetics) Boston University Schools of Medicine Boston MA USA

3. Department of Neurology Boston University Schools of Medicine Boston MA USA

4. Department of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth TX USA

5. The John P. Hussman Institute for Human Genomics University of Miami Miami FL USA

6. Department of Neurological Sciences and Rush Alzheimer's Disease Center Chicago IL USA

7. Department of Neuroscience Mount Sinai School of Medicine New York NY USA

8. Department of Psychiatry Mount Sinai School of Medicine New York NY USA

9. Department of Genetics and Genomic Sciences Mount Sinai School of Medicine New York NY USA

10. Department of Biology North Carolina A&T State University Greensboro NC USA

11. Department of Neuroscience Mayo Clinic Jacksonville FL USA

12. Department of Medicine University of Washington Seattle WA USA

13. Hope Center Program on Protein Aggregation and Neurodegeneration Washington University School of Medicine St Louis MO USA

14. Department of Psychiatry Washington University School of Medicine St Louis MO USA

15. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry Brigham and Women's Hospital and Harvard Medical School Boston MA USA

16. Program in Medical and Population Genetics Broad Institute Cambridge MA USA

17. Rush Institute for Healthy Aging, Department of Internal Medicine Rush University Medical Center Chicago IL USA

18. Department of Mental Health Johns Hopkins University School of Medicine Baltimore MD USA

19. Department of Medical & Molecular Genetics Indiana University Indianapolis IN USA

20. Department of Neurology University of Louisville Louisville KY USA

21. Department of Psychiatry Indiana University Indianapolis IN USA

22. Regenstrief Institute, Inc Indianapolis IN USA

23. Department of Medicine Indiana University Indianapolis IN USA

24. Department of Neurology and Neurosurgery, Sackler Faculty of Medicine Tel‐Aviv University Tel‐Aviv Israel

25. University of Pittsburgh Alzheimer's Disease Research Center and Department of Human Genetics, University of Pittsburgh Pittsburgh PA USA

26. Department of Biology Brigham Young University Provo UT USA

27. Department of Epidemiology University of Washington Seattle WA USA

28. National Alzheimer's Coordinating Center University of Washington Seattle WA USA

29. Department of Molecular Genetics, Brain Research Institute Niigata University Niigata Japan

30. Group Health Group Health Research Institute Seattle WA USA

31. National Center for PTSD, Behavioral Science Division Boston VA Healthcare System Boston MA USA

32. The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York NY USA

33. The Gertrude H. Sergievsky Center, College of Physicians and Surgeons Columbia University New York NY USA

34. Department of Pathology Stanford University Stanford CA USA

35. Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

36. Arizona Alzheimer's Consortium Phoenix AZ USA

37. Department of Psychiatry University of Arizona Phoenix AZ USA

38. Banner Alzheimer's Institute Phoenix AZ USA

39. Neurogenomics Division Translational Genomics Research Institute Phoenix AZ USA

40. The Department of Neurology, College of Physicians and Surgeons Columbia University New York NY USA

41. The Department of Psychiatry, College of Physicians and Surgeons Columbia University New York NY USA

42. The Department of Epidemiology, College of Physicians and Surgeons Columbia University New York NY USA

43. Tanz Centre for Research in Neurodegenerative Disease University of Toronto Toronto Canada

44. Cambridge Institute for Medical Research and Department of Clinical Neurosciences University of Cambridge Cambridge UK

45. PharmaTherapeutics Clinical Research Pfizer Worldwide Research and Development Cambridge MA USA

46. Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland OH USA

47. Department of Biostatistics Boston University Schools of Public Health Boston MA USA

48. Department of Ophthalmology Boston University Schools of Medicine Boston MA USA

49. Department of Epidemiology Boston University Schools of Public Health Boston MA USA

Funder

National Institutes of Health

National Institute on Aging

National Association for Colitis and Crohn's Disease

Boston University

Columbia University

Duke University

Emory University

Indiana University

Johns Hopkins University

Massachusetts General Hospital

Mayo Clinic

New York University

Northwestern University

Rush University

University of Alabama at Birmingham

University of Arizona

University of California, Davis

University of California, Irvine

University of California, Los Angeles

University of California, San Diego

University of California, San Francisco

University of Kentucky

University of Michigan

University of Pennsylvania

University of Pittsburgh

University of Southern California

University of Miami

University of Washington

Vanderbilt University

National Institute of Neurological Disorders and Stroke

GlaxoSmithKline

Banner Alzheimer’s Foundation

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

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