Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Author:

Lee Sven J.1,Teunissen Charlotte E.2,Pool René3,Shipley Martin J.4,Teumer Alexander5,Chouraki Vincent6,Melo van Lent Debora17,Tynkkynen Juho8,Fischer Krista9,Hernesniemi Jussi810,Haller Toomas9,Singh‐Manoux Archana411,Verhoeven Aswin12,Willemsen Gonneke3,Leeuw Francisca A.213,Wagner Holger1415,Dongen Jenny3,Hertel Johannes16,Budde Kathrin17,Willems van Dijk Ko181920,Weinhold Leonie21,Ikram M. Arfan122,Pietzner Maik17,Perola Markus2324,Wagner Michael715,Friedrich Nele17,Slagboom P. Eline25,Scheltens Philip13,Yang Qiong26,Gertzen Robert E.27,Egert Sarah28,Li Shuo26,Hankemeier Thomas12930,Beijsterveldt Catharina E.M.3,Vasan Ramachandran S.3132,Maier Wolfgang715,Peeters Carel F.W.33,Jörgen Grabe Hans1534,Ramirez Alfredo14153536,Seshadri Sudha3738,Metspalu Andres9,Kivimäki Mika4,Salomaa Veikko23,Demirkan Ayşe119,Boomsma Dorret I.3,Flier Wiesje M.1333,Amin Najaf1,Duijn Cornelia M.130

Affiliation:

1. Department of EpidemiologyErasmus Medical CenterRotterdamThe Netherlands

2. Neurochemistry Laboratory and BiobankDepartment of Clinical ChemistryVU University Medical CenterAmsterdam NeuroscienceAmsterdamThe Netherlands

3. Department of Biological PsychologyVrije Universiteit AmsterdamNeuroscience Campus AmsterdamAmsterdamThe Netherlands

4. Research Department of Epidemiology and Public HealthUniversity College LondonLondonUK

5. Institute for Community MedicineUniversity Medicine GreifswaldGreifswaldGermany

6. Lille UniversityInsermCHU LilleInstitut Pasteur de LilleU1167 ‐ RID‐AGE ‐ Risk Factors and Molecular Determinants of Aging‐Related DiseasesLabex DistalzLilleFrance

7. German Center for Neurodegenerative Diseases (DZNE)BonnGermany

8. University of TampereTampereFinland

9. The Institute of GenomicsUniversity of TartuTartuEstonia

10. Heart CenterTampere University HospitalTampereFinland

11. Inserm U1018Centre for Research in Epidemiology and Population HealthVillejuifFrance

12. Center for Proteomics and MetabolomicsLeiden University Medical CenterLeidenThe Netherlands

13. Alzheimer Center & Department of NeurologyAmsterdam NeuroscienceVU University Medical CenterAmsterdamThe Netherlands

14. Department of Psychiatry and PsychotherapyUniversity of BonnBonnGermany

15. Department for Neurodegenerative Diseases and Geriatric PsychiatryUniversity Hospital BonnBonnGermany

16. Department of Psychiatry and PsychotherapyUniversity Medicine GreifswaldGreifswaldGermany

17. Institute of Clinical Chemistry and Laboratory MedicineUniversity Medicine GreifswaldGreifswaldGermany

18. Einthoven Laboratory for Experimental Vascular MedicineLeiden University Medical CenterLeidenThe Netherlands

19. Department of Human GeneticsLeiden University Medical CenterLeidenThe Netherlands

20. Department of Endocrinology and Metabolic DiseasesLeiden University Medical CenterLeidenThe Netherlands

21. Department of Medical BiometryInformatics and EpidemiologyUniversity Hospital BonnBonnGermany

22. Department of Radiology and Nuclear MedicineErasmus Medical CenterRotterdamThe Netherlands

23. National Institute of Health and WelfareHelsinkiFinland

24. Institute for Molecular Medicine Finland (FIMM)University of HelsinkiHelsinkiFinland

25. Section of Molecular EpidemiologyLeiden University Medical CenterLeidenThe Netherlands

26. Department of BiostatisticsBoston University School of Public HealthBostonMAUSA

27. Division of Cardiovascular MedicineBeth Israel Deaconess Medical CenterBostonMAUSA

28. Department of Nutrition and Food SciencesNutritional PhysiologyUniversity of BonnBonnGermany

29. Division of Analytical BiosciencesLeiden Academic Centre for Drug ResearchFaculty of ScienceUniversiteit LeidenLeidenThe Netherlands

30. Translational EpidemiologyFaculty ScienceLeiden UniversityLeidenThe Netherlands

31. Department of MedicineBoston University School of MedicineBostonMAUSA

32. The Framingham Heart StudyFraminghamMAUSA

33. Department of Epidemiology & BiostatisticsAmsterdam Public Health Research InstituteVU University Medical CenterAmsterdamThe Netherlands

34. German Center for Neurodegenerative Diseases (DZNE)Rostock/GreifswaldGermany

35. Institute of Human GeneticsUniversity of BonnBonnGermany

36. Department of Psychiatry and PsychotherapyUniversity of CologneCologneGermany

37. Department of NeurologyBoston University School of MedicineBostonMAUSA

38. Glenn Biggs Institute of Alzheimer's and Neurodegenerative DiseasesUniversity of Texas Health Sciences CenterSan AntonioTXUSA

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Internationale Stichting Alzheimer Onderzoek

Hersenstichting

Directorate-General XII, Science, Research, and Development

Medical Research Council

British Heart Foundation

National Institute on Aging

National Institutes of Health

Academy of Finland

Bundesministerium für Bildung und Forschung

National Institute of Neurological Disorders and Stroke

National Institute of Diabetes and Digestive and Kidney Diseases

Eesti Teadusagentuur

Federal Ministry of Education and Research

German Federal Ministry of Education and Research

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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