Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Author:

Armato Ubaldo,Chiarini Anna,Chakravarthy Balu,Chioffi Franco,Pacchiana Raffaella,Colarusso Enzo,Whitfield James F.,Dal Prà Ilaria

Funder

Italian Ministry for University and Research

Publisher

Elsevier BV

Subject

Molecular Biology,Molecular Medicine

Reference101 articles.

1. γ-secretase-dependent proteolysis of transmembrane domain of amyloid precursor protein: successive tri- and tetrapeptide release in amyloid β-protein production;Takami;Int. J. Alzheimers Dis.,2012

2. Biochemistry of amyloid-β protein and amyloid deposits in Alzheimer disease;Masters,2012

3. Sequence determinants of enhanced amyloidogenicity of Alzheimer Aβ42 peptide relative to Aβ40;Kim;J. Biol. Chem.,2005

4. Decreased clearance of CNS beta-amyloid in Alzheimer's disease;Mawuenyega;Science,2010

5. The production of amyloid beta peptide is a critical requirement for the viability of central neurons;Plant;J. Neurosci.,2003

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