The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

Author:

Stevenson Glenn W.,Luginbuhl Amy,Dunbar Catherine,LaVigne Justin,Dutra Julio,Atherton Phillip,Bell Brooke,Cone Katherine,Giuvelis Denise,Polt Robin,Streicher John M.,Bilsky Edward J.

Funder

University of New England

NIAMS

NIH

Publisher

Elsevier BV

Subject

Behavioral Neuroscience,Biological Psychiatry,Clinical Biochemistry,Pharmacology,Toxicology,Biochemistry

Reference34 articles.

1. Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used;Adams;J Pharmacol Exp Ther,1993

2. 14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects;Ananthan;J Med Chem,2012

3. Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment;Avidor-Reiss;J Biol Chem,1995

4. Conditioned place preference: what does it add to our preclinical understanding of drug reward?;Bardo;Psychopharmacology (Berl),2000

5. Using antagonists to assess neurochemical coding of a drug's ability to establish a conditioned place preference;Bilsky;Pharm Biochem Behav,1990

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