Tyk2 Plays a Restricted Role in IFNα Signaling, Although It Is Required for IL-12-Mediated T Cell Function

Author:

Shimoda Kazuya,Kato Kouji,Aoki Kenichi,Matsuda Tadashi,Miyamoto Akitomo,Shibamori Masafumi,Yamashita Masakatsu,Numata Akihiko,Takase Ken,Kobayashi Shinji,Shibata Shouichirou,Asano Yoshinobu,Gondo Hisashi,Sekiguchi Kazuo,Nakayama Keiko,Nakayama Toshinori,Okamura Takashi,Okamura Seiichi,Niho Yoshiyuki,Nakayama Kei-ichi

Publisher

Elsevier BV

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Reference30 articles.

1. Interleukin 12 (IL-12) induces tyrosine phosphorylation of Jak2 and tyk2;Bacon;J. Exp. Med.,1995

2. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins;Darnell;Science,1994

3. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease;Durbin;Cell,1996

4. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of Stat1α and Stat3 complexes in human T cells and monocytes;Finbloom;J. Immunol.,1995

5. Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes;Firmbach-Kraft;Oncogene,1990

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