Integrating the escalation and dose expansion studies into a unified Phase I clinical trial-Reference-Cited by-同舟云学术

Integrating the escalation and dose expansion studies into a unified Phase I clinical trial

Published:2016-09 Issue: Volume:50 Page:124-134
ISSN:1551-7144
Container-title:Contemporary Clinical Trials
language:en
Short-container-title:Contemporary Clinical Trials

Author:

Iasonos Alexia,O'Quigley John

Funder

National Institute of Health

Publisher

Elsevier BV

Subject

Pharmacology (medical),General Medicine

Reference29 articles.

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2. Evolution of clinical trial design in early drug development: systematic review of expansion cohort use in single-agent phase I cancer trials;Manji;J. Clin. Oncol.,2013

3. A phase I/II seamless dose escalation/expansion with adaptive randomization scheme (SEARS);Pan;Clin. Trials,2014

4. Expansion cohorts in first-in-human solid tumor oncology trials;Theoret;Clin. Cancer Res.,2015

5. Nivolumab for metastatic renal cell carcinoma: results of a randomized Phase II trial;Motzer;J. Clin. Oncol.,2015

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