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Evolving cryo-EM structural approaches for GPCR drug discovery

  • Published:2021-09 Issue:9 Volume:29 Page:963-974.e6
  • ISSN:0969-2126
  • Container-title:Structure
  • language:en
  • Short-container-title:Structure

Author:

Zhang Xin,Johnson Rachel M.,Drulyte IevaORCID,Yu Lingbo,Kotecha Abhay,Danev RadostinORCID,Wootten Denise,Sexton Patrick M.,Belousoff Matthew J.

Funder

Takeda Science Foundation

Australian Research Council

National Health and Medical Research Council

Japan Science and Technology Agency

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference51 articles.

1. Real-space refinement in PHENIX for cryo-EM and crystallography;Afonine;Acta Crystallogr. D Struct. Biol.,2018

2. Structure of the adenosine A(2A) receptor bound to an engineered G protein;Carpenter;Nature,2016

3. Cryo-electron microscopy modeling by the molecular dynamics flexible fitting method;Chan;Biopolymers,2012

4. Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide;Chang;J. Biol. Chem.,2020

5. Routine sub-2.5 Å cryo-EM structure determination of B-family G protein-coupled receptors;Danev;bioRxiv,2020
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