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For X-irradiated normal human fibroblasts, only half of cell inactivation results from chromosomal damage

  • Published:2004-02 Issue:2 Volume:58 Page:445-452
  • ISSN:0360-3016
  • Container-title:International Journal of Radiation Oncology*Biology*Physics
  • language:en
  • Short-container-title:International Journal of Radiation Oncology*Biology*Physics

Author:

Borgmann Kerstin,Dede Mirco,Wrona Agnieszka,Brammer Ingo,Overgaard Jens,Dikomey Ekkehard

Publisher

Elsevier BV

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,Radiation

Reference54 articles.

1. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts;Di Leonardo;Genes Dev,1994

2. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after g-irradiation;Brugarolas;Proc Natl Acad Sci U S A,1999

3. P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest;Dulic;Cell,1994

4. High and low fluences of a-particles induce a G1 checkpoint in human diploid fibroblasts;Azzam;Cancer Res,2000

5. Apoptosis, p53 and tumor cell sensitivity to anticancer agents;Brown;Cancer Res,1999
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