Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists-Reference-Cited by-同舟云学术

Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists

Published:2008-03 Issue:6 Volume:18 Page:2089-2092
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Florjancic Alan S.,Peddi Sridhar,Perez-Medrano Arturo,Li Biqin,Namovic Marian T.,Grayson George,Donnelly-Roberts Diana L.,Jarvis Michael F.,Carroll William A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. On the Role of the P2X7 Receptor in the Immune System

2. Agonists and Antagonists Acting at P2X7 Receptor

3. Recent progress in the discovery of antagonists acting at P2X7receptor

4. Molecular Probes for P2X7 Receptor Studies

5. Discovery of P2X7receptor-selective antagonists offers new insights into P2X7receptor function and indicates a role in chronic pain states

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