Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimization-Reference-Cited by-同舟云学术

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimization

Published:2014-11 Issue:21 Volume:24 Page:5123-5126
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Alonso Juan Antonio,Andrés Miriam,Bravo Mónica,Calbet Marta,Eastwood Paul R.,Eichhorn Peter,Esteve Cristina,Ferrer Manel,Gómez Elena,González Jacob,Mir Marta,Moreno Imma,Petit Silvia,Roberts Richard S.,Sevilla Sara,Vidal Bernat,Vidal Laura,Vilaseca Pere,Zanuy Miriam

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs

2. Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

3. Prostaglandin D2 Receptor CRTH2 Antagonists for the Treatment of Inflammatory Diseases

4. Recent Advances in the Discovery and Development of CRTh2 Antagonists

5. Novel CRTH2 antagonists: a review of patents from 2006 to 2009

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reactivity of pyrazole derivatives with halomethanes: A DFT theoretical study;Journal of Molecular Modeling;2018-07-09

2. Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma;ACS Medicinal Chemistry Letters;2017-04-27

3. Recent advances of pyrrolopyridines derivatives: a patent and literature review;Expert Opinion on Therapeutic Patents;2017-01-27

4. Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy;Pharmacological Research;2016-09

5. Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists;European Journal of Medicinal Chemistry;2016-05