Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists-Reference-Cited by-同舟云学术

Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists

Published:2013-05 Issue:9 Volume:23 Page:2653-2658
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Stasi Luigi Piero,Artusi Roberto,Bovino Clara,Buzzi Benedetta,Canciani Luca,Caselli Gianfranco,Colace Fabrizio,Garofalo Paolo,Giambuzzi Silvia,Larger Patrice,Letari Ornella,Mandelli Stefano,Perugini Lorenzo,Pucci Sabrina,Salvi Matteo,Toro PierLuigi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

3. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

4. Distribution of orexin neurons in the adult rat brain1Published on the World Wide Web on 17 March 1999.1

5. Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

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