Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model-Reference-Cited by-同舟云学术

Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model

Published:2018-06 Issue:10 Volume:28 Page:1686-1692
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Yu Tao,Wu Chengde,Shih NengYang,Li Qi,Chan Chichung,Pan He,Yao Dan,Pan Yan,Liang Wei,Shen Liang,Zhao Hui,Li Jian,Chen Shuhui

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. DGAT and Triglyceride Synthesis A New Target for Obesity Treatment?

2. Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice

3. The DGAT1 Inhibitor LCQ908 Decreases Triglyceride Levels in Patients with the Familial Chylomicronemia Syndrome

4. The DGAT1 inhibitor Pradigastat Decreases Chylomicron Secretion and Prevents Postprandial Triglyceride Elevation in Humans

5. www.clinical.trials.

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Implementation of Genetic Algorithm-Ensemble Learning on QSAR Study of Diacylglycerol Acyltransferase-1(DGAT1) Inhibitors as Anti-diabetes;Data Science and Emerging Technologies;2023

2. Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes;Pharmaceuticals;2022-04-04

3. Bicyclic 6-6 Systems: Other Four Heteroatoms 2:2;Comprehensive Heterocyclic Chemistry IV;2022

4. Seven-Membered Rings;Progress in Heterocyclic Chemistry;2020

5. In silico design of diacylglycerol acyltransferase-1 (DGAT1) inhibitors based on SMILES descriptors using Monte-Carlo method;SAR and QSAR in Environmental Research;2019-07-23