Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX-Reference-Cited by-同舟云学术

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Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX

Published:2017-08 Issue:16 Volume:27 Page:3653-3660
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Shen Fa-Qian,Wang Zhong-Chang,Wu Song-Yu,Ren Shen-Zhen,Man Ruo-Jun,Wang Bao-Zhong,Zhu Hai-Liang

Funder

National Science & Technology

Public Science and Technology Research Fund Project of Ocean

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. Global cancer statistics;Jemal;CA Cancer J Clin,2011

2. Cancer: Inflaming metastasis;Mantovani;Nature,2009

3. Neutralizing tumor-promoting chronic inflammation: a magic bullet?;Coussens;Science,2013

4. Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX;Elkady;J Med Chem,2012

5. Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis;Lu;Bioorg Med Chem Lett,2016

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1. Design, synthesis and anti-oxidant activities of novel 1,2,3,4-tetrazine, 1,2,3-triazoles and coumarin derivatives and their nanoparticular encapsulation;Nano Express;2024-07-30

2. Precise cuts for tailoring chromene-phenyl COX inhibitors with Ligand Designer;Journal of Molecular Graphics and Modelling;2024-06

3. Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies;RSC Medicinal Chemistry;2024

4. Umbelliferone and Its Synthetic Derivatives as Suitable Molecules for the Development of Agents with Biological Activities: A Review of Their Pharmacological and Therapeutic Potential;Pharmaceuticals;2023-12-15

5. Dual-target inhibitors based on COX-2: a review from medicinal chemistry perspectives;Future Medicinal Chemistry;2023-12

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