Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties-Reference-Cited by-同舟云学术

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

Published:2016-09 Issue:18 Volume:26 Page:4455-4461
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

René Olivier,Fauber Benjamin P.,Barnard Adrian,Chapman Kerry,Deng Yuzhong,Eidenschenk Céline,Everett Christine,Gobbi Alberto,Johnson Adam R.,La Hank,Norman Maxine,Salmon Gary,Summerhill Susan,Wong Harvey

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference44 articles.

1. ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

3. Development and regulation of RORγt+ innate lymphoid cells

4. An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

5. Therapeutic opportunities of the IL-22–IL-22R1 system

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