Author:
Éliás Olivér,Nógrádi Katalin,Domány György,Szakács Zoltán,Kóti János,Szántay Csaba,Tarcsay Ákos,Keserű György M.,Gere Anikó,Kiss Béla,Kurkó Dalma,Kolok Sándor,Némethy Zsolt,Kapui Zoltán,Hellinger Éva,Vastag Mónika,Sághy Katalin,Kedves Rita,Gyertyán István
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
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1. Something's got to give: psychiatric disease on the rise and novel drug development on the decline
2. Unmet medical needs in depression are the following: better efficacy (longer time in remission, higher responder-rate), faster onset of action, effect on co-morbid symptoms and lack of side-effects of current medications; anxiety, psychosis, cognitive deficits are mostly regarded as comorbide symptoms; the main side-effects could for instance be: acute anxiogenesis, disturbed circadian rhythms and abnormal sleep, sexual dysfunction, pain and somatic complaints.
3. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs
4. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
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