Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization-Reference-Cited by-同舟云学术

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization

Published:2005-10 Issue:20 Volume:15 Page:4411-4416
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Deng James Z.,McMasters Daniel R.,Rabbat Philippe M.A.,Williams Peter D.,Coburn Craig A.,Yan Youwei,Kuo Lawrence C.,Lewis S. Dale,Lucas Bobby J.,Krueger Julie A.,Strulovici Berta,Vacca Joseph P.,Lyle Terry A.,Burgey Christopher S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Management of Atherothrombosis with Clopidogrel in High-Risk Patients with Recent Transient Ischaemic Attack or Ischaemic Stroke (MATCH): Study Design and Baseline Data

2. A new oral anticoagulant: the 50-year challenge

3. Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors

4. Dual Inhibitors of the Blood Coagulation Enzymes

5. Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides

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